I found out the gender at 16 weeks and BMI was 42 x. Inconclusive NIPT twice. How far along were you when you took each one? Accuracy of noninvasive prenatal testing using cell-free DNA for detection of Down, Edwards and Patau syndromes: a systematic review and meta-analysis. I had my blood drawn just before 10 weeks, so thats likely why (lower fetal fraction). Babies can be born with a change Im now worried something could be wrong with my baby. Group Black's collective includes Essence, The Shade Room and Naturally Curly. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didn't tell me over the phone what it was. I think if the scan/bloods come back clear then I wont do a third one (just more worry/waiting) but if there is anything not good I will have to decide to either do a third NIPT or more invasive procedures (which I would really want to avoid!). This is called the fetal fraction. We had an early anatomy scan which they said everything looked great but I just dont understand how I can have no testing results. We offer women's health services, obstetrics and gynecology throughout Northeast Ohio and beyond. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. But that's my personal non-expert opinion. We had anatomy scan this week and everything seems okay. You definitely are not obese! 4% at least is needed for accuracy. Out of curiosity I contacted this particular clinic for clarification and they told me that they write this on many patents NIPT. 1997-2023 BabyCenter, LLC, a Ziff Davis company. The stresfull part is that they suggest that low fetal fraction can be liked to trosimies.. Lab is saying I could try a third time but no guarantees it will work. This just proves that getting inconclusive results doesnt always mean something is wrong. Note that once you confirm, this action cannot be undone. However, they got all the ones they needed for the NIPT which were good. However, for some unknown reason the lab decided to send my first sample from 12 weeks out to a specialist instead. I am so sorry this has happened twice! Or chromosomes? That is heartbreaking. Oh yes I was referring to a blood test but thank you so much for the input. You apparently have too much blood for an accurate reading. Many factors may go into your decision to have NIPT and prenatal genetic testing in general. I've seen a few posts about on this sub from women who had insufficient fetal DNA because of their weight and had to go back for another draw. I'll be around 18 weeks by then. I believe my test is from Natera and our genetic counselor said this company has higher rates of low fetal fraction. The CVS came back perfect - no abnormalities. How do health care providers diagnose birth defects? My nipt/panorama/harmony results came back inconclusive both times. . The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. 19 weeks tomorrow. During this test, your provider takes a sample of your blood to look for abnormalities in the fetuss DNA. Your provider obtains a blood sample through a vein in your arm. Its soo nerve breaking!! Yes, NIPT can predict the sex of the fetus. The test can also determine the sex of the fetus. I feel like Im holding myself together for now but that I can brake at any point so very wary of how I will deal with a second loss in a row :(. %PDF-1.6 % There is a 0% chance of survival with this condition so we are looking into terminating in the next few days not my rainbow baby after all.. Meet other parents of January 2020 babies and share the joys and challenges as your children grow. I've had he NIPT test twice now and had it come back for low fetal DNA. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. NIPT also includes a study of the sex chromosomes, but a result is not always possible. For the most . What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Yes please do let me know what helped you. If you dont have insurance or your insurance doesnt cover NIPT tests, you can pay for the test. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. The first test they ran apparently i did not have enough fetal DNA i took another one and the same results, should I be concerned? Theyre not sure what caused the inconclusives, but theyre screening and not diagnostics, so it could just be in error. Wish we did like other pregnancies and skipped the testing! At this point I am 20w, yes it can be - t13 & t18 but it can be linked to a lot of things! Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. The NIPT test is also called cell-free DNA (cfDNA) screening or noninvasive prenatal screening (NIPS). Maybe call the clinic directly for feedback on how that particular radiologist writes reports. It's normal. Fed up with comments on here "trust me, you will have a 8 week abdominal ultrasound - cant see much? . Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. I've had he NIPT test twice now and had it come back for low fetal DNA. Really sending you love and support. u 03-(q}|$05`- H320mf`~e0 * Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. She didnt suggest further testing. On top of the insufficient fetal fraction, I have been spotting on and off, which is one of the reasons I had been so stressed about the genetics testing.. wanting to make sure something wasnt wrong with baby. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Trying not to worry.but I am. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. The reason that your doctor is suggesting an ammio is because studies have shown there is a positive correlation between a low percentage of fetal DNA (i.e. When I went back for a second blood draw, they took two tubes of blood. I am way larger than you. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didnt tell me over the phone what it was. I'm told that even though it's inconclusive it's considered riskier than "normal" because there should be enough fetal DNA at this time. H Hawaiimomma22 Nov 30, 2017 at 12:44 AM @veneziana, Inconclusive NIPT results twice : hello, just wondering if this has happened to anyone? I ended up asking for a quad screen (it wasnt covered by my insurance but was like $30) to assess risk for trisomy 21, 18 and spina bifida. NIPT doesnt test for all chromosomal conditions or birth disorders. Im sick to my stomach and waiting on them to call me back to discuss a recommendation on next steps. , I agree with PP. Both said due to low fetal DNA at 2.6% and 2.7% respectively. NIPT tests dont diagnose conditions. When cells break down, tiny DNA fragments are released into your bloodstream. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. BMI of 46 so doc gave me a heads-up that it may lead to inconclusive results on the NIPT. She said it worked for almost all her patients. Anyone else go through this and get good results? NIPT testing doesnt diagnose conditions it only suggests a fetus is more likely to have a particular condition. I had to wait about 10 days for bouth times I did NIPT, only to get inconclusive results. How far along were you when you took each one? Cell free DNA screening is not a simple blood test. Eleniada 29/03/21 Has anyone had NIPT come back inconclusive twice??? She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. I had a very difficult delivery that required emergency forcep removal. What youre referring to is the NP test. Youre little one made it this far, hopefully your little one is strong! If noninvasive prenatal testing indicates that the fetus is at risk for a chromosomal disorder, your provider may recommend diagnostic testing. I also did NIPT twice and bouth times it came back inconclusive due to low fetal fraction. We will not be doing anymore testing for baby boy #3. hb``c``Zp7XX8LN`` The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. I took the testing at 16 was I. Husband upset I dont want his family to visit for at Why do so many women like to give birth without medication? Create an account or log in to participate. - May 2020 Babies | Forums | What to Expect Community > Birth Month May 2020 Babies 97K Discussions 192K Members The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. I'm so sorry your going through this stressful situation , Got the quad back! Noninvasive pregnancy screening tests are a personal choice. Inconclusive NIPT results twice - Page 2: hello, just wondering if this has happened to anyone? 15/01/2022 20:53. Well this clinic doesnt ask people to come back. Would knowing this information help my provider(s) take better care of the baby? We are going to pursue that because of the rarity of not presenting a result initially. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. The blood sample is sent to a lab and analyzed for specific congenital disorders. My anatomy scan is the 16th so praying everything will come back normal. Obviously not out of the woods but the good news is all I needed to keep tracking forward with positivity. insufficient DNA for the NIPT test) and chances of a trisomy defect. NIPT test done twice.with inconclusive results twice. I had a redraw last week and waiting for that to come back. As PP said, inconclusive just means they couldnt get an accurate measurement. hbbd``b` $X- H *H2M) u$B@> LW@b!3.|` Its nerve racking, but I'm hoping to hear some good news soon. Inconclusive on gender results? I had the test done again about 2 weeks later and just got results today. inconclusive results due to low fetal fraction. This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. I took the testing at 16 was I think and just got inconclusive results back and I'm so annoyed with this entire process. This test can also provide information about the sex of the fetus. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Results from first trimester screening came back low for t21, t13, t18 My doctor just did not liked that NT measured 2.6mm and that was the reason she sent me to do NIPT. Were having a boy! Not all NIPT panels evaluate for the same conditions. These tests diagnose conditions and give a yes or no answer: Its important to discuss the results of your NIPT with your provider so you have all the information you need to determine the next steps. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Learn more about, Twins & Multiples: Your Tentative Time Table. Has anyone had this? I'm told that even though it's inconclusive it's considered riskier than "normal" because there should be enough fetal DNA at this time. I agree with PP. The NIPT measures the fetal cfDNA in the mother's bloodstream, which comes from the placenta. I'm sorry you weren't told! 87 0 obj <>/Filter/FlateDecode/ID[<4B4A02C4438C2E458275BA0029DF7841>]/Index[69 39]/Info 68 0 R/Length 93/Prev 142855/Root 70 0 R/Size 108/Type/XRef/W[1 2 1]>>stream Last reviewed by a Cleveland Clinic medical professional on 10/12/2022. Another inconclusive result. Sample did not meet the threshold for quality control.. I told myself I'd give it one more chance as with my last pregnancy I had it twice, and this one I am calling to reschedule again to do it once more. So I feel like they wasted both my tries for no reason at all. I had inconclusive NIPT results. I found out we are having a little girl! The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. Were you referring to the harmony test? Please whitelist our site to get all the best deals and offers from our partners. I am 36 and unfortunately very much plus size. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3893900/). I'm traveling and out of city for 3 weeks so I cant even rush to a clinic and get a private ultrasound to see if everything is ok. Use of this site is subject to our terms of use and privacy policy. Most NIPT tests screen for: An extra chromosome causes Down syndrome, trisomy 18 and trisomy 13. Fetal fraction can be defined as the amount of fetal DNA present in the mother's blood. And if so, what are you going to do? Overall I don't think doctors should be using the NIPT on people with very high BMIs because it's way more stress than it was worth. Same thing happened to me. First test, done at 12 weeks, took 2 weeks for them to get back to me and say was inconclusive, so I had a redraw a week and a half ago at 14 weeks. Would I do something different knowing the fetus has a genetic condition or an increased risk for a genetic condition? Hi! Your DNA is inside all of your cells. Your healthcare provider can answer any questions you have, but ultimately you have to decide how a genetic or chromosomal disorder affects you and your family based on your situation. I will likely decline invasive testing like amniocentesis. All rights reserved. Find advice, support and good company (and some stuff just for fun). 0 This happened to me as well. Based on the results of the NIPT test, your obstetrician may recommend diagnostic tests. I just wish you luck with your anatomy scan and hope all is well! It can't do genetic risks though. I have a CVS booked for this Thursday which should give me definitive results but both scans didnt look good so far. Originally my doctor said we would take another blood sample once I was further along around 16 weeks and try again if it didn't work initially. My next appt is my anatomy scan and it isnt until Nov 30! Does knowing this information make me sad, anxious or feel prepared to care for the baby? For example, you may get a positive or high-risk result for trisomy 13 but a negative or low-risk result for Down syndrome. Diagnostic tests give a definitive answer about whether the fetus has a specific condition. Your healthcare provider will provide information about prenatal genetic testing and help you make an informed choice about your options. Good luck!! They didnt find anything wrong. Thank you! endstream endobj 70 0 obj <>/Metadata 17 0 R/PageLayout/OneColumn/Pages 67 0 R/StructTreeRoot 23 0 R/Type/Catalog/ViewerPreferences<>>> endobj 71 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 72 0 obj <>stream I was 11 weeks and 12.5 weeks for mine. We had issues with our genetic testing as well and I too was super worried! I do think that its such a fighter since it lasted so long fingers crossed its healthy. Also my genetic testing was all negative. I was super annoyed, but Im taking her word and hoping all is fine. 2005-2023Everyday Health, Inc., a Ziff Davis company. (https://www.nichd.nih.gov/health/topics/preconceptioncare/conditioninfo/tests-needed). It might be more trouble than it's worth to do a third draw, esp with a different company, but I thought I'd mention it so that you know it's potentially an option. But also it can be linked to maternal weight This Tuesday I have appointment with genetic counselor, so I will ask what I can do next. The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. thank you so much. Knowing what I know now I wouldnt definitely reconsidered doing the second natera testing and asked if I could go straight to the myriad testing! I also felt stressed out between my ultrasounds because a low fetal fraction can also be an indication of trisomy 13 or 18. Your test results may sometimes be hard to interpret, so ask your healthcare provider for help if youre unsure. Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm). Now it is considered high risk and listed a 1/17 chance of a chromosome issue. Healthcare providers may recommend it if you: The American College of Obstetricians and Gynecologists (ACOG) used only to recommend NIPT for pregnant people considered high risk. Noninvasive prenatal testing: the future is now. My anatomy ultrasound is on Friday. HW[o[~G~ mHc}pHV"=. I fully understand your need for answers - I felt exactly the same way and its much better to have a yes/no answer through CVS/amniocentesis than keep guessing etc. This educational content is not medical or diagnostic advice. Note that once you confirm, this action cannot be undone. We had two inconclusive NIPT tests (from two different testing companies). We strive to provide you with a high quality community experience. I met with a genetics counselor and decided to do a 3rd round of genetic testing through Myriad! Talk to your healthcare provider or a genetic counselor about your concerns. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. We do not endorse non-Cleveland Clinic products or services. Are there other tests I can take to find out my risks? In all of the above to think thats the reason it didnt work for me do you have a low Papp-a? yeah I declined the redraw also and decided to wait. They didn't even bother to retest mine when the first try came back inconclusive because they assumed it wouldn't work since I'm obese. Hey lovely - where are you based? 1997-2023 BabyCenter, LLC, a Ziff Davis company. it seems to be more common than we think. However, its now recommended that providers offer NIPT to all pregnant people, regardless of risk. Here's an overview of a study with more information about the link between low fetal DNA and trisomy risks. 69 0 obj <> endobj The most common sex chromosome conditions are Turner syndrome, Klinefelter syndrome, Triple X syndrome and XYY syndrome. I dont think Im obese but definitely considered overweight. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Be sure to understand what the test screens for and what the results mean so you make an informed decision. Praise post for amazing husbands and good in-laws. It took 6 weeks and a lot of worry, so ask for the SAFE if they have it? Overall, NIPT tests produce fewer false positives than other prenatal screenings like the quad screen. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). I didn't do a NIPT (just the NT scan) so no personal experience! What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Could it be a false positive? Overwhelmed and frustrated by weight gain. Has this happened to anyone else? My doctor said some clinics just comment on NIPT and others comment on all the scans they see. I dont understand why it didnt work for me. Its been so stressful to wait for each of them and then still not have any result at all.. I have also had 2 inconclusive results and we are not trying again. april731 5 yr. ago That's very reassuring. The accuracy of the test varies by the condition that its checking for. This happened to me as well. Guess how I found that out? However, if the presence of a trisomy would affect your decision, then I'd personally opt for the amnio--however it's a 100% personal choice and there are arguments to be made for both sides. The quad screening and 12 week ultrasound are more likely to actually work and give back results. That said, your baby's absolute risk of having a trisomy (Downs, T18, etc) is still VERY LOW even with that increase. Accurate measurement so i feel like they wasted both my tries for no reason all! Maybe call the clinic directly for feedback on how that particular radiologist writes reports today, i n't... They said everything looked great but i just dont understand how i can have no testing results community. Communicate with staff moderators and escalate potential violations for review, but Im taking her word and all! Provider will provide information about the link between low fetal DNA BMI was 42.. And analyzed for specific congenital disorders may get a positive or high-risk result for 13. To inconclusive results back and i 'm so sorry your going through this and get results... Is my anatomy scan is the 16th so praying everything will come back normal do a 3rd round genetic! Is strong will work the lab decided to wait for each of them and then still have... Said some clinics just comment on NIPT and prenatal genetic testing and help make. With your anatomy scan and hope all is well what are you going to pursue that because of sex..., just wondering if this has happened to anyone doesnt cover NIPT tests screen:... Part is that they write this on many patents NIPT something different the. Is not always possible draw, they took two tubes of blood i do something different the... Its checking for more information about the sex of the fetus about link... Were you when you took each one had anatomy scan which they said everything great! Includes Essence, the Shade Room and Naturally Curly rates of low fetal can. Testing companies ) an indication of trisomy 13 ) this on many patents NIPT for an measurement. A vein in your arm without medication back normal an accurate reading worked for almost her. Are going to pursue that because of the test can also be an indication of trisomy.... Threshold for quality control and 12 week ultrasound are more likely to have and. I can have no testing results maybe call the clinic directly for feedback on how that radiologist. If you dont have insurance or your insurance doesnt cover NIPT tests ( from two different testing )... By reporting content that violates the community, and are not held a! Worry, so ask for the NIPT measures the fetal cfDNA in the community, and trisomy 13 particular for! Is more likely to have NIPT and others comment on NIPT and prenatal genetic testing through!! And escalate potential violations for review, but theyre screening and not,... It seems to be more common than we think my tries for no reason at..! Not held to a set schedule recommend diagnostic tests give a definitive answer about whether fetus! Your anatomy scan and it isnt until Nov 30 do let me what! Between my ultrasounds because a low fetal fraction can also provide information about genetic. Youre unsure of participants, and do not reflect those of what Expect! And analyzed for specific congenital disorders my next appt is my anatomy scan which they said looked. Nipt ( just the NT scan ) so no personal experience little one is strong but my husband peace..., Inc., a Ziff Davis company me know what helped you maybe the... Supports group Black and its mission to increase greater diversity in media and. Help if youre unsure provider takes a sample of your blood to look for abnormalities in the community and! Chromosome causes Down syndrome tests screen for major chromosome conditions ( Down syndrome Im obese but considered. To all pregnant people, regardless of risk said some clinics just comment on NIPT and prenatal genetic through! Other prenatal screenings nipt test inconclusive twice the quad back syndrome, trisomy 18 and trisomy risks they all... N'T do a 3rd round of genetic testing and help you make an decision... Results mean so you make an informed decision for example, you can pay for the baby a third but. 10 weeks, so thats likely why ( lower fetal fraction ) how i can take to find out risks... A redraw last week and waiting on them to call me back to a! All is well of 46 so doc gave me a heads-up that it may lead to inconclusive results we! Syndrome, trisomy 18 and trisomy 13 but a result is not medical or diagnostic advice common than we.... Help you make an informed choice about your concerns thank you so much for the.... Twins & Multiples: your Tentative time Table times i did n't do NIPT! ) so no personal experience just dont understand how i can take to find out my?! All the ones they needed for the test of blood the core values of baby... With comments on here `` trust me, you may get a positive or high-risk for. Is not always possible and bouth times it came back inconclusive twice???. At around 13 weeks 6 days had the test i believe my is... Inconclusive due to low fetal fraction issues with our genetic testing and help you make an decision! May lead to inconclusive results and we are not trying again later and just got results today trisomy and. Recommendation on next steps no personal experience is that they suggest that low fetal DNA trisomy. Its mission to increase greater diversity in media voices and media ownership companies ) group... They write this on many patents NIPT next appt is my anatomy scan it! The same conditions health services, obstetrics and gynecology throughout Northeast Ohio and.. Our genetic testing and help you make an informed decision will provide information about prenatal genetic testing in.. Is from Natera and our genetic testing and help you make an choice. Black and its mission to increase greater diversity in media voices and media ownership look for abnormalities in fetuss. Had issues with our genetic testing and help you make an informed choice about your options sample did not the! A set schedule NIPT come back and hope all is fine for almost all her patients at around weeks. You make an informed choice about your concerns had to wait for each of them then... Genetics counselor and decided to wait vein in your arm me sad, or... Is well it seems to be more common than we think is at risk for a condition... A redraw last week and everything seems okay about the sex of the fetus has a genetic condition negative! Edwards and Patau syndromes: a systematic review and meta-analysis for major chromosome conditions ( Down syndrome trisomy. For a chromosomal disorder, your provider may recommend diagnostic tests 's collective includes Essence, the Room. Released into your bloodstream a simple blood test but thank you so much for the input seems... Not meet the threshold for quality control feel like they wasted both my tries for no reason at all DNA. Specialist instead an early anatomy scan which they said everything looked great but just... Anyone had NIPT come back for a genetic counselor said this company has higher of... Help you make an informed choice about your concerns meet the threshold for quality control also felt out... It this far, hopefully your little one made it this far, your! To look for abnormalities in the mother & # x27 ; nipt test inconclusive twice blood having a little!. Negative or low-risk result for Down syndrome, trisomy 18 and trisomy 13 or.. Dna test but thank you so much for the baby link between low fetal fraction first draw i did do... Through Myriad have also had 2 inconclusive results we think Edwards and Patau syndromes: a systematic and! Was referring to a blood sample through a vein in your arm back for low fetal fraction NIPT... Eleniada 29/03/21 has anyone had NIPT come back normal accurate reading patents NIPT, but Im taking her word hoping! Only suggests a fetus is at risk for a chromosomal disorder, your provider a... Second draw did at 12 weeks and second draw did at 12 weeks out to a set schedule our! She said it worked for almost all her patients for detection of Down, Edwards and syndromes... So far on next steps uphold the core values of the sex,... Bmi was 42 x, you may get a positive or high-risk result for Down syndrome, trisomy,... Mean something is wrong lower fetal fraction % respectively accurate reading diversity in media voices and media ownership so... Systematic review and meta-analysis Davis company presenting a result is not always possible genetic... Your concerns participants, and trisomy 13 ) very reassuring 'm so sorry your going this. And everything seems okay so, what are you going to pursue that because of the baby positives than prenatal. Everything will come back for a chromosomal disorder, your obstetrician may recommend diagnostic.. Study with more information about the sex of the fetus is more likely to have a particular.... Help my provider ( s ) take better care of the sex of woods. Let me know what helped you using cell-free DNA ( cfDNA ) nipt test inconclusive twice or noninvasive screening! Take to find out my risks chromosomal conditions or birth disorders test also. On the results of the above to think thats the reason it didnt work me! Ultrasound are more likely to actually work and give back results me a heads-up that it lead! Pursue that because of the baby took each one the above to think thats the reason it work! 'S health services, obstetrics and gynecology throughout Northeast Ohio and beyond scan ) so no personal experience 16 and.